Milk Thistle Prescription Drug Interactions

Milk Thistle Prescription Drug Interactions
Suggested Reading: Is it safe to use herbs with drugs?
Milk Thistle is one of the ingredients in Dr. Miller’s Holy Tea

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by Neva J. Howell unless otherwise noted

Potential Interactions and Side Effects with Milk Thistle
Except for any noted source material, content copyright, Neva. J. Howell, all rights reserved

This is part of my personal favorable experience using Dr. Miller’s Holy Tea

Precautions to consider when taking Milk Thistle, to rule out prescription drug interactions:

I found more potential drug interactions with Milk Thistle than any of the other ingredients in the Holy Tea. I also found an impressive list of potential benefits.

It is up to each person to carefully review these and other potential side effects or drug interactions before deciding to use any formula containing milk thistle.

In particular, talk with your doctor before using milk thistle if you are being treated with:

protease inhibitors
anti-seizure meds
ergot drugs
antidepression drugs
statin drugs * are statins safe?
transplant drugs


This is a partial list of prescription drugs that might cause serious drug interactions when combined with milk thistle:

ambien, ativan, baycol, clozaril, effexor, erythromycin, halcion, hismanal, lescol, luvox, mepron
methadone, mevacor, orap, nizoral, paxil, pravachol, prepulsid, prozac, rhythmol, rifampin, seldane
serzone, sporanox, tambocor, tegretol, versed, wellbutrin, zocor, zyban

Despite the rather long list of potential drug interactions with milk thistle, there are about as many situations where milk thistle appears to protect from harmful prescription drug side effects. In other words, certain meds can create a situation where the addition of milk thistle might provide vital protection AGAINST harmful effects associated with medication.

Some of these drugs include lovastatin, halperidol, anesthesia, chemotherapy, tacrine, pravastatin, metronidazole, clofibrate, fluororacil, paclitazel and others. Again, consult with your doctor as well as a knowledgeable nutritionist and herbalist to determine whether milk thistle could be a useful protective herb to add in those situations.

Pregnant women and nursing mothers should always check with their doctor before taking any type of natural remedy, regardless of how harmless it may be for the non-pregnant and non-nursing person.

Herbs that could cause interactions or unintended result if combined with milk thistle:
St. John’s Wort

Note: Just because St. John’s Wort is the only herb I know about that might cause a reaction with milk thistle, that doesn’t mean it’s the only herb that might so self-monitoring when using more than one herb or drug is always advisable.

Health benefits associated with Milk Thistle:

Milk thistle has long been considered a potent reliever of congestion, specifically in the liver, spleen and kidneys. Milk thistle shows protective properties when used by those who overuse alcohol too, and is considered benefical to help protect the liver from damage from such abuse. This herb is also being studied for it’s aggressive properties against cancer and other viral hepatitis.

One interesting and quite specific use of milk thistle is as an antidote to deathcap mushroom poisoning, which will only be helpful if you happen to ingest deathcap mushrooms.

more about milk thistle benefits here

Back to Product Review of Holy Tea as Constipation Remedy

2 thoughts on “Milk Thistle Prescription Drug Interactions

  1. Milk thistle with some herbs may be useful for many disease and specially the pigmentation disease like vitiligo.

    vitiligoguide dot com

  2. Irshad: I did not know about milk thistle for vitiligo. I visited your site and noticed that the product you promote for vitiligo does not contain it. If there’s an article on milk thistle and vitiligo there that I missed, please let me know where it is. I will glean info from it and post it here for my readers.

    I did also look at the product you mentioned, antivitiligo, and it looks to be based on some good herbal ingredients.

    I’m aware of barberry root, coconut oil and black cumin. Psoralea Coryli Folia was a new one for me.

    In looking for it online, I was redirected to Psoralea corylifolia so I’m assuming it’s the same thing.

    Found some interesting info on that here:

    That page lists Psoralea corylifolia as useful for skin related problems and even elephantiasis. Also, interestingly enough, it is used for cavities in teeth.

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